Famous reptile enthusiast Brian Barczyk has sadly passed away after spending 10 days in hospice care ... following a brave battle with pancreatic cancer.

The announcement was made Monday ... with the folks at his Reptarium Reptile Zoo paying tribute to their "exceptional" visionary, mentor and friend in an emotional IG statement ... where they praised Brian's ability to touch innumerable hearts and minds globally with his fervent passion for reptiles and wildlife.

They added, "For those of us who had the privilege of working alongside him, Brian's absence leaves an immeasurable void. As we navigate this difficult time, we find comfort in the memories and the lasting light of Brian's work. He will be deeply missed but indeed, never forgotten."

Brian received news of his devastating stage four pancreatic cancer diagnosis almost a year ago ... and it looks like he knew what was coming as just days earlier, he shared an emotional goodbye video.

The reptile influencer once said ... "I'm ready, guys. It was a tough year. It was so painful, the pain was incredible, the sickness was incredible, the treatment was incredible, everything about it was so bad" ... while also thanking his "reptile army" for their support.

Brian made a career out of his love for reptiles ... starring on the Discovery Channel's "Venom Hunters" and kickstarting his successful YouTube career in 2016. He had 5.26 million subscribers and collaborated with the likes of Logan and Jake Paul.

As well his Reptarium Reptile Zoo, he was also the founder of Legasea Aquarium.

He also owned the third-largest collection of snakes in the world -- over 30,000, actively participating in venom milking.

He leaves behind his wife Lori and their two children, Noah and Jade. A memorial in honor of Brian will be held on Wednesday by his family in Sterling Heights, Michigan.