Rep. George Santos just got booted from Congress ... after the House voted to expel him following a controversial time in office, which includes multiple felony charges.

Santos is the first member of Congress not convicted of a felony to be expelled since the Civil War. Only 6 members have been expelled in U.S. history.

The vote to expel Santos was 311 - 114. Among those voting to expel ... 105 Republicans.

A defiant Santos refused to resign Thursday before Friday's vote ... but he's out of Congress now nonetheless.

Remember ... Santos was arrested back in May on a variety of felony charges, including lying, wire fraud, money laundering, theft of public funds and making false statements to the House of Representatives.

Santos had escaped two previous votes to expel him from Congress, but the third time was not a charm for him.

The difference this time ... a recent House Ethics Committee report claiming evidence of Santos' alleged federal law violations. Among the report's juicy claims -- Santos allegedly used campaign funds for OnlyFans and Botox.

During his time in office, Santos was surrounded by controversy and accusations of lying his way to Congress ... he made a few friends, but even more enemies ... often sparring with media and, most recently, some anti-Israel protestors.